2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N15280
    Terrestrimine 1778735-31-1 98%
    Terrestrimine is a potent inhibitor of α-Glycosidase, with the IC50 of 225.83 μM. Terrestrimine plays an important role in metabolic disease research.
    Terrestrimine
  • HY-N15524
    Thalictoside 74213-96-0 98%
    Thalictoside is found in A. squamosa L. Thalictoside is a sEH inhibitor (IC50: 20.2 µM). Thalictoside exerts anti-osteoporotic effects through an estrogen-like mechanism. Thalictoside can be used in the research of cardiovascular and urinary diseases.
    Thalictoside
  • HY-N15525
    Arabinothalictoside 153287-94-6 98%
    Arabinothalictoside is found in A. squamosa L. Arabinothalictoside is a sEH inhibitor (IC50: 47.1 µM). Arabinothalictoside can be used in the research of cardiovascular and urinary diseases.
    Arabinothalictoside
  • HY-N15575
    Rhamnitol 1114-16-5 98%
    Rhamnitol is the reduction product of L-rhamnose that can be found in the metabolism of ingested rhamnose in the body. Rhamnitol is promising for research of intestinal permeability assessment and carbohydrate metabolism.
    Rhamnitol
  • HY-N15635
    Withacoagin 119539-81-0 98%
    Withacoagin is a withanolide that can be isolated from the roots of Withania coagulans. Withacoagin has various biological activites such as adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin regulates the activity of various enzymes and pathways related to oxidative stress and inflammation. Withacoagin can attenuates HIV-1 infection.
    Withacoagin
  • HY-N15684
    Rhodoxanthin 116-30-3 98%
    Rhodoxanthin is a carotenoid. Rhodoxanthin exerts antioxidant activity via free radical scavenging and lipid peroxidation inhibition. Rhodoxanthin is promising for research of oxidative stress-related diseases (e.g., UV-induced skin damage).
    Rhodoxanthin
  • HY-N15691
    Tadehaginoside 2020004-61-7
    Tadehaginoside, a phenylpropanoid glycoside, is a regulator of lipogenesis and glucose consumption. Tadehaginoside has antioxygenic property. Tadehaginoside mediates liver protection against oxidative stress injury and inflammation by regulating Nrf2 and NF-κB signaling pathways in hepatocytes. Tadehaginoside can be used for the study of obesity and diabetes.
    Tadehaginoside
  • HY-N15697
    Prinsepiol 82667-99-0 98%
    Prinsepiol ((-)-Prinsepiol) is an antioxidant agent targeting free radical scavenging. Prinsepiol exerts antioxidant activity via direct free radical neutralization and modulation of oxidative stress-related pathways. Prinsepiol is promising for research of liver injury repair and oxidative stress-related diseases.
    Prinsepiol
  • HY-N15706
    Luteolin-7-O-β-D-glucuronide methyl ester 76939-42-9
    Luteolin-7-O-β-D-glucuronide methyl ester is a flavonoid with antioxidative activity. Luteolin-7-O-β-D-glucuronide methyl ester exhibits potent antioxidative activity with an IC50 of 3.05 μg/mL in the NBT superoxide scavenging assay. Luteolin-7-O-β-D-glucuronide methyl ester inhibits LDL oxidation induced by Cu2+ with the IC50 value is 71.13 μg/mL.
    Luteolin-7-O-β-D-glucuronide methyl ester
  • HY-N15728
    2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside 94356-36-2
    2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside (Compound 5) is an orally active chromone glycoside found in the roots of Rumex patientia. 2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related fields such as inflammation and metabolic diseases.
    2-(2'-Hydroxypropyl)-5-methyl-7-hydroxychromone-7-O-β-D-glucopyranoside
  • HY-N15754
    3-Hydroxy-2-methylglutaric acid 54665-33-7
    3-Hydroxy-2-methylglutaric acid is a carboxylic acid metabolite. 3-Hydroxy-2-methylglutaric acid can be isolated from the flower Veronica incana L. 3-Hydroxy-2-methylglutaric acid can be used for upper respiratory tract diseases, malignant neoplasms, gastrointestinal tract and genitourinary system disorders and diabetes mellitus research.
    3-Hydroxy-2-methylglutaric acid
  • HY-N15768
    Tauro-3β,5α,6β-trihydroxycholanoic acid sodium 1917340-42-1
    Tauro-3β,5α,6β-trihydroxycholanoic acid sodium is a bile acid (BA) suitable to investigate BAs and their relatives’ behavior and correlation with liver, gallbladder, and bile ducts diseases.
    Tauro-3β,5α,6β-trihydroxycholanoic acid sodium
  • HY-N15772
    16:0 Folate cap PE disodium 2456348-69-7 98%
    16:0 Folate cap PE is a lipid layer containing phospholipid surfactant. 16:0 Folate cap PE can be used to prepare lipid nanoparticles for drug delivery.
    16:0 Folate cap PE disodium
  • HY-N15780
    Hirudinoidine A 1021944-70-6
    Hirudinoidine A is a pteridine. Hirudinoidine A can be isolated from the Hirudo nipponica Whitman. Hirudinoidine A can be used for diabetic nephropathy research.
    Hirudinoidine A
  • HY-N15781
    Trans-faazo-4 1882060-21-0
    Trans-FAAzo-4 is a photo-switchable fatty acid analogue used in photo-pharmacology. Trans-FAAzo-4 is able to alter membrane lateral pressure and thus control opening and closing of mechanosensitive ion channels.
    Trans-faazo-4
  • HY-N15784
    Tauro-12-oxolithocholanoic acid sodium 2707415-29-8
    Tauro-12-oxolithocholanoic acid sodium is a bile acid (BA) suitable to investigate BAs and their relatives’ behavior and correlation with liver, gallbladder, and bile ducts diseases.
    Tauro-12-oxolithocholanoic acid sodium
  • HY-N15785
    18:0-Azo PC 2098674-45-2
    18:0-azo PC is an analog of phosphatidylcholine (PC). Under light, 18:0-azo PC can be switched on and off by light, forcing the azobenzene portion of the molecule to undergo cis/trans isomerization, leading to the initiation or termination of cell signaling.
    18:0-Azo PC
  • HY-N15821
    30:0 Coenzyme A ammonium 2260795-81-9 98%
    30:0 Coenzyme A ammonium is a vital cofactor in various metabolic processes, particularly in the citric acid cycle and fatty acid metabolism.
    30:0 Coenzyme A ammonium
  • HY-N15876
    18:1-6:0 DNP-C11 BODIPY 505/515 TG 2260795-52-4 98%
    18:1-6:0 DNP-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to study the effects of phosphoinositides (Ex/Em = 495/503 nm).
    18:1-6:0 DNP-C11 BODIPY 505/515 TG
  • HY-N15883
    18:1-C11 BODIPY 505/515-C11 BODIPY 505/515 TG 2260795-51-3
    18:1-C11 BODIPY 505/515-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to measure triacylglycerol hydrolases (Ex/Em = 495/503 nm).
    18:1-C11 BODIPY 505/515-C11 BODIPY 505/515 TG
Cat. No. Product Name / Synonyms Application Reactivity